Elucidate dystonia pathophysiology in animal models of neonatal brain injury using in vivo electrophysiology, chronic and acute neural circuit manipulation using chemogenetics and quantitative motor behavior characterization.
Optimize dystonia prediction in people at risk for cerebral palsy using magnetic resonance imaging and epidemiological analyses.
Optimize dystonia diagnosis by changing the status quo of dystonia diagnosis from qualitative to quantitative assessment using machine-learning assisted approaches in animal models of neonatal brain injury and in people with cerebral palsy.